Opportunity Information: Apply for PAR 25 333
The NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed), funding opportunity number PAR-25-333, is a National Institutes of Health (NIH) career development award run by the National Institute of Dental and Craniofacial Research (NIDCR). Its central goal is to build and sustain a strong pipeline of dentist-scientists with dual doctoral training who can become independently funded investigators focused on improving dental, oral, and craniofacial health. In practical terms, the program is meant to shorten the time between postdoctoral training and a stable, independent faculty research position by providing structured support that begins with mentored training and then transitions into independent research funding.
The award is organized as a two-phase mechanism. The first phase (K99) provides up to two years of mentored support for outstanding dual degree dentist-scientists who are currently in postdoctoral research positions and still need targeted training, strong mentorship, and protected time to publish, deepen methodological expertise, and build a competitive independent research direction. The second phase (R00) supports the move into independence by providing three to five years of research support once the awardee secures an independent, tenure-track or equivalent faculty position. A notable feature of this particular opportunity is the built-in flexibility to extend the independent R00 phase to five years to accommodate clinical training in a dental specialty program, as long as that clinical training does not exceed 3 person-months of effort (equivalent to 25% full-time professional effort) in any single year of the R00 phase. This structure is intended to reflect the real-world career demands on clinician-scientists who may need to balance advanced clinical credentialing with building an independent research laboratory or program.
As stated in the title, clinical trials are not allowed under this funding opportunity, meaning the proposed work must fit within NIH definitions of non-clinical-trial research for this mechanism. Applicants should be prepared to frame their research plans accordingly and ensure the proposed aims do not trigger clinical trial classification under NIH rules.
Eligibility for applicant organizations is broad across U.S.-based institutions and includes many common NIH applicant types: public and private institutions of higher education, public and state-controlled universities, nonprofits (both 501(c)(3) and non-501(c)(3) entities that are not institutions of higher education), for-profit organizations (other than small businesses) as well as small businesses, and multiple levels of government entities (state, county, city/township, and special district governments). It also includes independent school districts, public housing authorities/Indian housing authorities, and Native American tribal governments (federally recognized) along with Native American tribal organizations that are not federally recognized tribal governments. The opportunity also explicitly lists additional eligible applicants such as eligible federal agencies, faith-based or community-based organizations, Indian/Native American tribal governments that are not federally recognized, regional organizations, and U.S. territories or possessions. At the same time, foreign organizations are not eligible to apply as applicant institutions, and non-U.S. components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, which generally means certain parts of the research may be conducted abroad or involve international collaboration when well-justified and consistent with NIH policy, even though the applicant institution itself must be U.S.-based.
From an administrative standpoint, this is a discretionary grant opportunity in the health funding category (CFDA 93.121). The posting shows an original closing date of May 7, 2028, and a creation date of June 17, 2025. The notice does not specify an award ceiling or the expected number of awards in the provided source data, so applicants typically need to consult the full NIH announcement and related NIDCR guidance for budget structure, allowable costs, and current NIH/NIDCR funding expectations.
Overall, this K99/R00 is designed for dual degree dentist-scientists who are ready to make the jump from mentored postdoctoral work to an independent faculty career, and it tries to remove common bottlenecks by combining mentored career development with a clear, funded path into an independent appointment, including a built-in option to accommodate limited clinical specialty training during the independent phase without derailing research momentum.Apply for PAR 25 333
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
- This funding opportunity was created on 2025-06-17.
- Applicants must submit their applications by 2028-05-07.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQ)
What is this grant opportunity?
The NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed), funding opportunity number PAR-25-333, is an NIH career development award administered by the National Institute of Dental and Craniofacial Research (NIDCR). It is designed to help dual degree dentist-scientists transition from mentored postdoctoral research to a stable, independent faculty research career focused on improving dental, oral, and craniofacial health.
What is the main purpose of the K99/R00 mechanism in this program?
The central goal is to build and sustain a strong pipeline of dentist-scientists with dual doctoral training by shortening the time between postdoctoral training and an independent, tenure-track (or equivalent) faculty research position. The structure provides mentored support first, then transitions to independent research funding once a faculty position is secured.
Which NIH institute runs this opportunity?
This opportunity is run by NIDCR, the National Institute of Dental and Craniofacial Research, which is part of the National Institutes of Health (NIH).
What does "Dual Degree Dentist Scientist" mean in the context provided?
Based on the description, the opportunity targets dentist-scientists with dual doctoral training (dual doctoral degrees) who are pursuing research careers in dental, oral, and craniofacial health. The program is specifically described as supporting "dual degree dentist-scientists."
How is the award structured?
The award has two phases:
- K99 phase: Up to 2 years of mentored support for eligible candidates in postdoctoral research positions who need targeted training, strong mentorship, and protected research time.
- R00 phase: 3 to 5 years of support to help the awardee move into independence after securing an independent, tenure-track or equivalent faculty position.
How long can the mentored (K99) phase last?
The K99 phase can provide up to two years of mentored support.
How long can the independent (R00) phase last?
The R00 phase provides three to five years of research support once the awardee secures an independent, tenure-track or equivalent faculty position.
When does the R00 phase begin?
The R00 phase is intended to begin once the awardee secures an independent, tenure-track or equivalent faculty position.
Who is the K99 phase designed for?
The K99 phase is intended for outstanding dual degree dentist-scientists who are currently in postdoctoral research positions and still need additional targeted training and mentorship, along with protected time to publish, deepen methodological expertise, and develop a competitive independent research direction.
What is the program trying to help applicants accomplish during the K99 phase?
During the K99 phase, the program emphasizes mentored training and protected time to:
- Publish research results
- Deepen methodological expertise
- Build a competitive, independent research direction
What is a notable flexibility feature of this specific opportunity?
A key feature is flexibility to extend the independent R00 phase to five years to accommodate clinical training in a dental specialty program, provided the clinical training effort does not exceed 3 person-months (25% full-time professional effort) in any single year of the R00 phase.
How does the opportunity treat clinical specialty training during the R00 phase?
Clinical training in a dental specialty program can be accommodated during the R00 phase by allowing the independent phase to extend up to five years, as long as the clinical training does not exceed 3 person-months of effort (25% full-time professional effort) in any single R00 year.
What does the limit of 3 person-months (25% effort) mean for clinical training during R00?
It means that in any year of the R00 phase, the awardee may devote no more than 3 person-months of effort (equivalent to 25% full-time professional effort) to clinical specialty training if they are using the built-in flexibility described for this program.
Are clinical trials allowed under this opportunity?
No. Clinical trials are not allowed under this funding opportunity. The title explicitly states "Clinical Trial Not Allowed," and the description notes that proposed work must fit NIH definitions of non-clinical-trial research for this mechanism.
How should applicants handle the "clinical trial not allowed" restriction?
Applicants should frame their research plans so the proposed aims do not trigger classification as a clinical trial under NIH rules, ensuring the project fits within NIH definitions of non-clinical-trial research for this mechanism.
What types of institutions can apply as the applicant organization?
Eligibility for applicant organizations is broad across U.S.-based institutions and includes:
- Public and private institutions of higher education
- Public and state-controlled universities
- Nonprofits (501(c)(3) and non-501(c)(3) entities that are not institutions of higher education)
- For-profit organizations (other than small businesses), as well as small businesses
- State, county, city/township, and special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Native American tribal governments (federally recognized) and Native American tribal organizations that are not federally recognized tribal governments
- Eligible federal agencies
- Faith-based or community-based organizations
- Indian/Native American tribal governments that are not federally recognized
- Regional organizations
- U.S. territories or possessions
Are foreign organizations eligible to apply as the applicant institution?
No. Foreign organizations are not eligible to apply as applicant institutions for this opportunity.
Are non-U.S. components of U.S. organizations eligible to apply?
No. Non-U.S. components of U.S. organizations are not eligible to apply as applicant institutions under this opportunity.
Are foreign components allowed at all?
Yes. Foreign components are allowed as defined by the NIH Grants Policy Statement. This generally means certain parts of the research may be conducted abroad or include international collaboration when well-justified and consistent with NIH policy, even though the applicant institution must be U.S.-based.
What is the funding opportunity number?
The funding opportunity number is PAR-25-333.
What is the CFDA number and funding category listed?
The listing shows CFDA 93.121, and the funding category is health.
What type of grant is this from an administrative standpoint?
The posting describes this as a discretionary grant opportunity.
What are the key dates shown in the provided information?
The provided information includes a creation date of June 17, 2025, and an original closing date of May 7, 2028.
Does the provided information list an award ceiling or the expected number of awards?
No. The provided source data does not specify an award ceiling or the expected number of awards.
Where should applicants look for budget structure, allowable costs, and current funding expectations?
The provided information indicates applicants typically need to consult the full NIH announcement and related NIDCR guidance for budget structure, allowable costs, and current NIH/NIDCR funding expectations.
What kinds of careers is this award intended to support?
This K99/R00 is intended to support dual degree dentist-scientists in progressing from mentored postdoctoral research into an independent faculty investigator career with a research focus on improving dental, oral, and craniofacial health.
What is the intended benefit for clinician-scientists who need advanced clinical credentialing?
The structure is intended to reflect real-world clinician-scientist career demands by allowing an option to accommodate limited clinical specialty training during the independent phase without derailing research momentum, provided the clinical effort limit is met.
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