Opportunity Information: Apply for HT9425 23 OCRP CTRA

The Ovarian Cancer Clinical Translational Research Award (Funding Opportunity Number HT9425 23 OCRP CTRA) is a Department of Defense program administered through the Department of the Army (USAMRAA) that supports translational research tightly connected to a clinical trial in ovarian cancer. The central purpose is to fund correlative studies that use clinical trial-linked patient data and specimens to identify and validate relationships between biological or contextual factors and meaningful ovarian cancer outcomes. These factors can include genetic changes, biochemical markers, environmental exposures, and other measurable variables that may influence how ovarian cancer starts, progresses, spreads (metastasis), returns (recurrence), or responds to an intervention. The emphasis is on translational work that can move the field toward more actionable clinical insights, especially in areas where there are clear gaps or unmet needs.

A defining feature of this award is the requirement that the research be associated with a clinical trial that is past, currently ongoing, or planned for the future. Rather than funding a standalone laboratory project, the mechanism is meant to leverage the clinical trial setting where patient populations are well-defined, treatments and outcomes are tracked, and biospecimens may be available with strong clinical annotation. The goal is to connect what is observed in patients (such as treatment response, survival, recurrence patterns, or adverse effects) with molecular or other correlates that can improve prognosis, diagnosis, or therapeutic decision-making.

The types of activities envisioned under this opportunity include deeper molecular analysis of clinical samples collected through trials, validation of candidate biomarkers, and extended clinical follow-up of patients who were enrolled in trials that are still open, ongoing, or already completed. Projects can be structured as hypothesis-driven studies that test specific predictions, or as efforts that generate broadly useful resources for the ovarian cancer research community. Examples of these resource-oriented outputs include clinically annotated tissue arrays and patient-derived experimental platforms (such as patient-derived models), where specimens are paired with detailed clinical metadata and molecular characterization to enable future discovery and validation work.

From an administrative standpoint, this opportunity is listed as a discretionary program in the Science and Technology and other Research and Development category (CFDA 12.420). The eligible applicant pool is described as unrestricted, meaning it is broadly open to different types of entities, subject to any additional eligibility clarifications in the full announcement. The funding instruments include grants and cooperative agreements, indicating that awards could involve either a more traditional investigator-led structure or a model with closer government involvement depending on the specific award conditions. The opportunity was created on March 7, 2023, with an original closing date of July 21, 2023, and it anticipated making one award; the published award ceiling is listed as 0, which typically signals that the maximum funding level was not specified in the summary record and would need to be confirmed in the full solicitation.

Overall, the program is designed to accelerate clinically relevant ovarian cancer discoveries by tying molecular and other correlates directly to clinical trial contexts, with the intent of producing insights and tools that can inform diagnosis, prognosis, patient stratification, and the real-world impact of interventions.

  • The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "Ovarian Cancer Clinical Translational Research Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on Mar 07, 2023.
  • Applicants must submit their applications by Jul 21, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)

What is the Ovarian Cancer Clinical Translational Research Award (CTRA)?

The Ovarian Cancer Clinical Translational Research Award (Funding Opportunity Number HT9425 23 OCRP CTRA) is a Department of Defense research program administered through the Department of the Army (USAMRAA). It supports translational ovarian cancer research that is tightly connected to a clinical trial, with a central focus on correlative studies that link patient data and specimens to meaningful clinical outcomes.

What is the main purpose of this funding opportunity?

The central purpose is to fund correlative studies that use clinical trial-linked patient data and biospecimens to identify and validate relationships between biological or contextual factors and ovarian cancer outcomes. The goal is to move toward more actionable clinical insights, especially where there are clear gaps or unmet needs.

What does "translational research" mean in the context of this award?

In this program, translational research means work that connects observations in patients (such as response to treatment, survival, recurrence, or adverse effects) with molecular or other correlates derived from clinical trial-linked samples and data. The intent is to produce findings that can inform diagnosis, prognosis, or therapeutic decision-making in a clinically relevant way.

Is a clinical trial required for an application to be responsive?

Yes. A defining feature of this award is that the proposed research must be associated with a clinical trial that is past, currently ongoing, or planned for the future. The mechanism is not meant to fund a standalone laboratory project that is disconnected from a clinical trial context.

What kinds of clinical trials qualify (past, ongoing, or planned)?

The opportunity allows association with clinical trials that are already completed, currently ongoing, or planned for the future. The key requirement is that the research is tied to a clinical trial context where patient populations are well-defined, treatments and outcomes are tracked, and biospecimens may be available with strong clinical annotation.

What are "correlative studies" in this program?

Correlative studies are analyses that relate measurable factors (for example, molecular features in specimens or other variables) to clinical outcomes observed in the clinical trial setting. This includes identifying and validating relationships between factors and outcomes such as response to an intervention, survival, recurrence patterns, metastasis, or adverse effects.

What types of factors can be studied under this award?

Factors can include genetic changes, biochemical markers, environmental exposures, and other measurable variables that may influence how ovarian cancer starts, progresses, spreads (metastasis), returns (recurrence), or responds to an intervention.

What outcomes is the program trying to connect to these factors?

The program aims to connect factors to meaningful ovarian cancer outcomes, including treatment response, survival, recurrence patterns, metastasis, and adverse effects, as tracked within a clinical trial setting.

What kinds of research activities are envisioned?

Examples of activities include deeper molecular analysis of clinical samples collected through trials, validation of candidate biomarkers, and extended clinical follow-up of patients enrolled in trials that are still open, ongoing, or already completed.

Are projects required to be hypothesis-driven?

Not necessarily. Projects can be structured as hypothesis-driven studies that test specific predictions, or as efforts that generate broadly useful resources for the ovarian cancer research community.

What does it mean to "generate resources" for the research community?

Resource-oriented outputs described in the opportunity include items like clinically annotated tissue arrays and patient-derived experimental platforms (such as patient-derived models). These resources are characterized by specimens paired with detailed clinical metadata and molecular characterization so they can support future discovery and validation work.

What are examples of deliverables mentioned in the opportunity?

The opportunity specifically mentions clinically annotated tissue arrays and patient-derived experimental platforms (including patient-derived models) as examples of outputs that can enable future research, especially when combined with clinical metadata and molecular characterization.

Why does the award emphasize a clinical trial setting?

The clinical trial setting provides well-defined patient populations, tracked treatments and outcomes, and potentially available biospecimens with strong clinical annotation. This structure helps connect laboratory or molecular observations directly to real patient outcomes and intervention effects.

What is the administering organization for this opportunity?

The program is a Department of Defense effort administered through the Department of the Army, specifically via USAMRAA.

What is the program category and assistance listing referenced?

Administratively, the opportunity is listed as a discretionary program in the Science and Technology and other Research and Development category, under CFDA 12.420.

Who is eligible to apply?

The eligible applicant pool is described as unrestricted, meaning it is broadly open to different types of entities, subject to any additional eligibility clarifications that may be provided in the full announcement.

What funding instruments are used for this opportunity?

The opportunity lists grants and cooperative agreements as the funding instruments. This indicates that awards could be made under a traditional investigator-led grant structure or under a cooperative agreement model that may involve closer government involvement, depending on award conditions.

How many awards were anticipated?

The summary indicates the opportunity anticipated making one award.

What was the opportunity timeline in the summary record?

The opportunity was created on March 7, 2023, and the original closing date listed in the summary record was July 21, 2023.

What is the award ceiling for this opportunity?

The published award ceiling is listed as 0 in the summary record. This typically indicates the maximum funding level was not specified in that summary and would need to be confirmed in the full solicitation.

What clinical impact is this program aiming for?

The program is designed to accelerate clinically relevant ovarian cancer discoveries by tying correlates directly to clinical trial contexts. It aims to produce insights and tools that can inform diagnosis, prognosis, patient stratification, and understanding of the real-world impact of interventions.

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